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KMID : 1134820120410010087
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Journal of the Korean Society of Food Science and Nutrition
2012 Volume.41 No. 1 p.87 ~ p.94
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A Study on the Bioavailability of Organic Ca in Growing Rats
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Park Mi-Na
Cho Su-Jung
Kim Hee-kyong
Kim Jae-hong
Kim Min-ho
Kim Wan-Sik
Lee Yeon-Sook
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Abstract
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We evaluated the bioavailability of a novel organic Ca supplement chelated with milk protein (CaMP) in growing rats and compared it with those of Ca carbonate and Ca citrate. Four-week-old male rats were divided into six groups (n=6/group) and fed AIN-93G-based experimental diets containing three Ca sources, Ca carbonate, Ca citrate, and CaMP at two levels, normal (0.5%, w/w) and high (1.5%, w/w), for 6 weeks. Growth, mineral contents of serum, Ca content and breaking force of femur, and Ca absorption were measured. There were no significant differences in weight gain or food intake, but food efficiency ratio (FER) of CaMP in the high Ca group was higher than those of other groups. Ca and P concentrations in serum were within normal range in all experimental rats. There was no difference in Ca content of the femur among all of the groups. Although there was no statistical significance in bone breaking force of the femur among the groups, the CaMP groups had a higher breaking force compared to other groups. Further, Ca absorption rate significantly increased in the CaMP groups (p<0.05). These results demonstrate that the CaMP supplement did not exhibit any negative effect on growth or Ca metabolism of the rats. Therefore, CaMP can be recommended as a good Ca supplement with regard to bone metabolism and Ca bioavailability.
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KEYWORD
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organic Ca, milk protein, bioavailability, physiological function, bone metabolism
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